Abstract ---Botulism,
a potential lethal disease related to neurologic complications caused by neurotoxins
most of then were produced by Clostridium botulinum. Food related botulism, infant
botulism and wound botulism were reported all over the world after the first published
by Kerner in 1820, botulism of adult with unknown was distributed in recent year
which may due to colonization in gastrointestinal tract or toxin produced in vitro.
The botulinal neurotoxin is the most lethal biological substance known, and it
can be purified in laboratory. Bioterrorism is discussed after the terrier attack
of United State in 2001 and botulism is one of the most possible agents. Prevention
to the attack of biological weapons is impossible, it is emergent that clinicians
should learn to recognize, diagnose and manage this rare but lethal disease, include
the possibility of large outbreak due to terrorism. |