Abstract
---Plague is a zoonotic illness caused by the Gram-negative bacillus
Yersinia pestis. Human are not necessary for persistence of the organism, and
we acquire plague from animal fleas, contact with infected animals or rarely from
other humans via aerosols or direct contact with infected secretions. To be able
to differentiate endemic plague from plague used in biological warfare, medical
officers must understand the typical way in which humans contract plague in nature:
First, a die-off of animals in the mammalian reservoir that harbors bacteria-infected
fleas will occur. Second, troops who have been in close to infected mammals will
become infected. By contrast, plague will spread via aerosols in the most likely
biological warfare. A rapid person to person spread of fulminant pneumonia would
then occur. If an enemy force is to release fleas infected with Y pestis, then
people would present with classic bubonic plague before a die-off in the local
mammalian reservoirs occur. The three clinical forms of human plague are bubonic,
septicemic and pneumonic. Bubonic plague, characterized by painful lymphadenopathy
and severe constitutional symptoms of fever, chills and headache, is the most
common form. Septicemic plague without localized lymphadenopathy occurs less commonly
and is difficult to diagnose. Primary pneumonic plague is spread by airborne transmission
and has the highest mortality. Diagnosis is established by identifying the organism
from blood or other body fluids. Patients should be isolated initially and treated
with antibiotics (streptomycin preferably) early. A killed, whole-cell vaccine
is available to protect humans against bubonic plague, but not against for primary
pneumonic plague. |